Hi,
I have configured the dispatcher default socket as below IP , the expectation here is that kamailio should send all traffic from this IP (port will be ephemeral) over TCP.
modparam("dispatcher", "ds_default_socket", "tcp:172.27.45.219:5060")

This system also listens on port 8080 which is meant for websocket communication (dispatcher communication is over non websocket).

Kamailio is sending an OPTION message to dispatcher IP over TCP on 5060 and getting 200 OK response but Kamailio considering the response is on websocket port 8080 ,$Rp value is 8080.

onreply_route {
     if (($Rp == 8080 ) && !(proto == WS))
        {
                xlog("L_WARN", "SIP response received on $Rp protocol:proto RIP:$Ri SIP:$si method:$rm cid:$ci replystatus:$rs len:$ml\n");
                xlog("L_WARN", "SIP message received: $mb\n");
                drop;
        }

.....
....
}

Following is the output of above logs:
Jun 24 15:10:08 localhost /usr/sbin/kamailio[6223]: WARNING: {2 10 OPTIONS 1ab6573a4640823b-6209@172.27.45.198} <script>: SIP response received on 8080 protocol:tcp  RIP:172.27.45.219 SIP:172.27.44.125 method:OPTIONS cid:1ab6573a4640823b-6209@172.27.45.198 replystatus:200 len:416

Jun 24 15:10:08 localhost /usr/sbin/kamailio[6223]: WARNING: {2 10 OPTIONS 1ab6573a4640823b-6209@172.27.45.198} <script>: SIP message received: SIP/2.0 200 OK#015#012Via: SIP/2.0/TCP 172.27.45.198:5060;branch=z9hG4bK4526.92b79f34000000000000000000000000.0;received=172.27.45.219#015#012From: <sip:dispatcher@localhost>;tag=1ae6c95d92f9ea9ce927f715de5c48c8-eb141029#015#012To: <sip:172.27.44.125:5060;transport=tcp>;tag=a9d542e0#015#012Call-ID: 1ab6573a4640823b-6209@172.27.45.198#015#012CSeq: 10 OPTIONS#015#012Allow: INVITE, ACK, BYE, OPTIONS, CANCEL, INFO, UPDATE, NOTIFY#015#012Content-Length: 0


Also I have attached a pcap.

Dispatcher.list configuration:
1 sip:172.27.44.125:5060;transport=tcp 0 0 duid=sample-cas;maxload=1000

Thanks,
Shahid