On Tue, Jul 03, 2018 at 09:11:55AM -0400, Mike Little wrote:

Sorry if this has already been answered but can Kamailio be configured to support clustering

Yes.

and use Anycast?

Anycast is handled at a different layer, don't see why it couldn't be used (not that I know anything about anycast).

We are looking to use Kamailio as a front end to Asterisk as the registar and presence server.

A common request.

If this is supported, are there any documents that explain how to configure this type of setup?

Googeling for "kamailio asterisk registrar presence integration" results among other: http://kb.asipto.com/asterisk:realtime:kamailio-4.0.x-asterisk-11.3.0-astdb But there are many ways to implement this.

Same for clustering. You could use DMQ: https://www.kamailio.org/docs/modules/5.1.x/modules/dmq.html or a clustered SQL backend.

If this is your first introduction to kamailio, better split your questions in small (independent) projects.